Application of nano-curcumin as a natural antimicrobial agent against Gram-positive pathogens

Gram-positive bacteria cause various diseases from the superficial skin to deep tissue infections. The capability of causing numerous is due production virulence factors which are tightly regulated by genes. Various pathogenic e.g. Staphylococcus, Mycobacterium, and Listeria capable lethal infections in humans animals. Conventional antibiotics, targeted combinatorial drugs used as therapeutic agents against pathogens. Due intricate pathway readily adopt resistance available drugs. Therefore, there need develop some alternative approaches combat these natural extracts effective with or without Curcumin a extract Curcuma longas rhizome, known turmeric. shows biological activities such antimicrobial, antioxidant anti-inflammatory. It also strong antibacterial activity few Gram-negative bacteria. Besides all beneficial applications, major drawbacks curcumin poor aqueous solubility less bioavailability. However, drug delivery including nanoformulation developed increase its stability vitro vivo settings. present review article focused on translation potential applications specifically caused methods for formulations nanoparticles, strategies nanoparticles their application prevention have been discussed. discusses future aspects curcumin-nanoparticles use an approach